Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets.

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Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets.

Curr Med Chem. 2015 Aug 17;

Authors: Dos Santos Fernandes GF, Jornada DH, de Souza PC, Chin CM, Pavan FR, Dos Santos JL

Abstract
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values < 7 µM, low toxicity and a high selective index. In addition, emerging targets in MTB are presented to provide new perspectives for the discovery of new anti-tubercular drugs. This review aims to summarize the current advances in and promote insights into anti tubercular drug discovery.

PMID: 26282941 [PubMed - as supplied by publisher]