Dapagliflozin: The outcome of use as add-on therapy in real-life clinical setting -An Audit

J Pak Med Assoc. 2021 Sep;71(9):2214-2216. doi: 10.47391/JPMA.01-117.


OBJECTIVE: Dapagliflozin is the first novel sodium glucose co transporter 2 inhibitor for the treatment of Type 2 diabetes. The aim of this audit was to evaluate its effectiveness and safety in a real-life clinical setting.

METHODS: We analyze data from four UK district general hospitals on patients initiated on dapagliflozin. HbA1c, weight and daily insulin dosage was recorded at baseline and 6 months follow-up.

RESULTS: At baseline, mean HbA1c was 82±19.21mmol/mol(9.7%) and mean weight was 102±18.1kg. The average reduction in HbA1c at 6 months was 13±7.23 mmol/mol (1%) whereas the average reduction in weight was 2 ±2.02 kg.. A mean reduction in daily insulin requirement by 12±8.3 units at 6 months compared to baseline was noted. There were certain complications in patients taking insulin and gliclazide including candidiasis, urinary tract infection and hypoglycaemia, and 4% patients discontinued dapagliflozin due to side effects.

CONCLUSIONS: Our results confirm that dapagliflozin can be used safely and effectively in a real-life setting.

PMID:34580517 | DOI:10.47391/JPMA.01-117