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Dermatological manifestations of fungal infection in patients with febrile neutropenia: A review of the literature.

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Dermatological manifestations of fungal infection in patients with febrile neutropenia: A review of the literature.

Mycoses. 2019 May 09;:

Authors: Maddy AJ, Sanchez N, Shukla BS, Maderal AD

Abstract
BACKGROUND: Febrile neutropenia is a common cause of morbidity and mortality in immunocompromised patients. Although most infections are caused by bacterial pathogens, fungal infections are becoming increasingly more common. Due to its rarity, the diagnosis of fungal infections in febrile neutropenic patients is often delayed.
OBJECTIVE: To provide current clinical features, epidemiology, etiology, diagnosis and treatment of cutaneous involvement of fungal infection in patients with febrile neutropenia.
METHODS: A retrospective literature review of Pubmed was performed, with no language or publishing data restrictions, yielding 116 results. We queried each case for cutaneous lesions associated with fungal pathogens in febrile neutropenia.
RESULTS: We found 54 publications with 215 reported cases of cutaneous manifestations of fungal injury in patients with febrile neutropenia.
LIMITATIONS: This study is limited in that it is a literature review of a disease that is likely underreported.
CONCLUSION: Cutaneous lesions caused by yeasts such as Candida and Trichosporon manifest as diffuse erythematous papules and usually do not develop central necrosis or eschar, while molds will present as tender nodules that subsequently develop eschar and necrosis. Recognizing the cutaneous manifestations of fungal disease can assist in the diagnosis and management of these infections. This article is protected by copyright. All rights reserved.

PMID: 31069853 [PubMed - as supplied by publisher]