Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying.

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Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying.

Chem Commun (Camb). 2020 Oct 07;:

Authors: Luz I, Stewart IE, Mortensen NP, Hickey AJ

Abstract
Inhalable metal organic framework (MOF) aerosols have been developed via spray drying as a therapy for multi-drug resistant (MDR) tuberculosis (TB). The CuPOA2 (pyrazinoate acid) MOFs can be tailored to exhibit a respirable mass median aerodynamic diameter (MMAD) of 2.6 μm. This method is repeated to manufacture Gd0.1Cu0.9(POA)2 MOFs for inhalable theragnostics.

PMID: 33025961 [PubMed - as supplied by publisher]