Detection of KPC-2 and qnrS1 in clinical isolates of Morganella morganii from China.

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Detection of KPC-2 and qnrS1 in clinical isolates of Morganella morganii from China.

Diagn Microbiol Infect Dis. 2012 Jun;73(2):207-9

Authors: Cai JC, Yang W, Hu YY, Zhang R, Zhou HW, Chen GX

Abstract
Seven carbapenem-nonsusceptible Morganella morganii isolates, which have similar antibiotic susceptibility profiles, were isolated over a 5-month period. MICs of imipenem, meropenem, and ertapenem were 8, 1, and 0.25 to 0.5 μg/mL, respectively. Pulsed-field gel electrophoresis indicated that 6 isolates were indistinguishable or closely related. Carbapenem resistance can be transferred from M. morganii to Escherichia coli by conjugation. All M. morganii isolates and E. coli transconjugants produced KPC-2 and carried the qnrS1 gene. Production of KPC-2 mainly contributed to the carbapenem resistance in M. morganii. KPC-2-producing M. morganii clonally spread in a hospital in China.

PMID: 22542894 [PubMed - indexed for MEDLINE]