Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy.

Related Articles

Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy.

Med Mycol Case Rep. 2019 Sep;25:25-28

Authors: Lester R, Church D, Ambasta A

Abstract
Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment.

PMID: 31334000 [PubMed]