Effect of drug resistance on negative conversion of sputum culture in patients with pulmonary tuberculosis.
Int J Infect Dis. 2015 Dec 9;
Authors: Kim J, Kwak N, Lee HY, Kim TS, Kim CK, Han SK, Yim JJ
OBJECTIVE: Negative conversion of sputum culture is a useful marker for predicting treatment outcome and relapse of pulmonary tuberculosis (TB). We evaluated the effect of drug resistance on negative conversion of sputum culture with treatment.
DESIGN: A total of 535 patients with culture-proven pulmonary TB were classified into three groups: drug susceptible (DS), other drug resistance (ODR), and multidrug resistance/extensive drug resistance (MDR/XDR). Rates of conversion of sputum culture at 4, 8, and 12 weeks were compared.
RESULTS: At 4 weeks of treatment, the conversion rate in the DS group (52.7%) was higher than that in the ODR group (30.8%, P=0.003), but it was not different compared with the MDR group (45.7%, P=0.427). At 8 weeks, the conversion rate in the DS group (76.3%) was higher than that in the ODR (63.5%, P=0.042) and MDR groups (60.0%, P=0.031). At 12 weeks, the conversion rate in the DS group (85.9%) tended to be higher than that in the MDR group (74.3%, P=0.062), but was not different from that in the ODR group (84.6%, P=0.796).
CONCLUSION: The pattern of resistance to anti-TB drugs affects culture conversion rates at the early phase of treatment and also prolongs the time to culture conversion.
PMID: 26692454 [PubMed - as supplied by publisher]