Evaluation of MIC strip isavuconazole test for susceptibility testing of wild type and non-wild-type A. fumigatus isolates.

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Evaluation of MIC strip isavuconazole test for susceptibility testing of wild type and non-wild-type A. fumigatus isolates.

Antimicrob Agents Chemother. 2016 Oct 31;:

Authors: Arendrup MC, Verweij P, Nielsen HV

Abstract
We evaluated the "MIC Strip Isavuconazole" test against EUCAST E.Def 9.3 using 40 wild-type and 39 CYP51A mutant A. fumigatus Full (FIE) and 80% growth inhibition (80%-IE) strip endpoints were determined by two independent readers (R1/R2). The essential (within ±0, ±1 and ±2 two-fold dilutions) and categorical agreement were best for the FIE (R1/R2: 42%/41%, 75%/73% and 90%/89%, and 91.1%/92.4%, with 6.3/8.9% VMEs and 0/1.3% MEs, respectively). The isavuconazole strip test with FIE appears useful.

PMID: 27799223 [PubMed - as supplied by publisher]