Evaluation of the efficacy of amphotericin B, posaconazole, voriconazole and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense.

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Evaluation of the efficacy of amphotericin B, posaconazole, voriconazole and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense.

Antimicrob Agents Chemother. 2013 Oct 7;

Authors: Fernández-Silva F, Capilla J, Mayayo E, Sutton DA, Hernández P, Guarro J

Abstract
We evaluated and compared the efficacy of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus in a murine model of systemic infection. Three clinical strains of this fungus were tested and the therapies administered were as follows: posaconazole at 20 mg/kg (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction and by (1→3)-β-D-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates never were higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-D-glucan serum levels were equally reduced by all drugs evaluated.

PMID: 24100490 [PubMed - as supplied by publisher]