Evaluation of the gradient concentration strip method for antifungal susceptibility testing of isavuconazole and comparators for Mucorales species.
Antimicrob Agents Chemother. 2019 Jul 29;:
Authors: Vidal P, Schwarz P, Dannaoui E
MIC values for amphotericin B and three azoles determined by the EUCAST reference technique and by gradient concentration strips were compared for 30 Mucorales isolates belonging to clinically important species. Essential agreement (EA) within +/- 2 dilution steps at 24 hours between the techniques was 83.3% for isavuconazole. For the comparators, EA for itraconazole, amphotericin B and posaconazole was 86.7%, 73.3%, and 56.7%, respectively. A good agreement was obtained between visual and spectrophotometric reading for EUCAST.
PMID: 31358578 [PubMed - as supplied by publisher]