Evaluation of the gradient concentration strip method for antifungal susceptibility testing of isavuconazole and comparators for Mucorales species.

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Evaluation of the gradient concentration strip method for antifungal susceptibility testing of isavuconazole and comparators for Mucorales species.

Antimicrob Agents Chemother. 2019 Jul 29;:

Authors: Vidal P, Schwarz P, Dannaoui E

Abstract
MIC values for amphotericin B and three azoles determined by the EUCAST reference technique and by gradient concentration strips were compared for 30 Mucorales isolates belonging to clinically important species. Essential agreement (EA) within +/- 2 dilution steps at 24 hours between the techniques was 83.3% for isavuconazole. For the comparators, EA for itraconazole, amphotericin B and posaconazole was 86.7%, 73.3%, and 56.7%, respectively. A good agreement was obtained between visual and spectrophotometric reading for EUCAST.

PMID: 31358578 [PubMed - as supplied by publisher]