Evaluation of the vaginal microbiome in clinical diagnosis and management of vaginal infectious diseases.
Chin Med J (Engl). 2019 Mar 19;:
Authors: Li T, Liu ZH, Li K, Bai HH
OBJECTIVE: The Vaginal Microecology Evaluation System (VMES) is a technical and economically feasible tool to assess the vaginal microbiomes of gynecological outpatients. The aim of this review was to introduce knowledge on the potential changes that can occur in the vaginal microbiome and how to use the Evaluation System to diagnose and manage a broad range of vaginal infections.
DATA SOURCES: This review was based on data in articles published in PubMed up to December 10, 2018, with the following keywords: "Vaginal microecosystem", "vaginal microbiome", "vaginal microbiota", and "vaginal flora".
STUDY SELECTION: Original articles and critical reviews on VMES and vaginal microbiota selected for this review. References of the retrieved articles were also screened to search for potentially relevant papers.
RESULTS: Any imbalance in the naturally occurring vaginal bacterial flora may result in infections such as bacterial vaginitis, aerobic vaginitis, vulvovaginal candidiasis, or Trichomonas vaginalis. VMES is mainly composed of morphological and functional microecological indicators. The former diagnostic modality includes bacterial density, flora diversity, dominant bacterial flora, indicators of inflammation, pathogenic microorganisms, Nugent score, and AV score. Functional indicators consist of two main components: metabolites and microbial enzymes.
CONCLUSIONS: The establishment of VMES has a high clinical value in the treatment of vaginal infections. It opens up new opportunities for the comprehensive management of dysbacteriosis when such infections occur.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.
PMID: 30896565 [PubMed - as supplied by publisher]