Fatal VAP-related pulmonary aspergillosis by Aspergillus niger in a positive COVID-19 patient

Respir Med Case Rep. 2021 Feb 18:101367. doi: 10.1016/j.rmcr.2021.101367. Online ahead of print.

ABSTRACT

Invasive pulmonary aspergillosis, known as a complication in patients with severe respiratory syndromes, recently showed a correlation with COVID-19 pneumonia, and the clinical characteristics of COVID-19 associated pulmonary aspergillosis (CAPA) have been described. Unfortunately, infections by the Aspergillus genus are often diagnosed in post-mortem time, because of diagnostic delays and a rapid worsening of respiratory conditions. Literature data document, in fact, only few cases of COVID-19 Aspergillus niger coinfection. The aim of this study was to describe a case of a VAP-related probable pulmonary aspergillosis by Aspergillus niger in a COVID-19 patient. Despite the definition of fungal etiology and the rapid administration of antifungal therapy, the patient died while on ventilator support because of severe respiratory impairment.

PMID:33619451 | PMC:PMC7890353 | DOI:10.1016/j.rmcr.2021.101367