Favorable outcome of chronic disseminated candidiasis in four pediatric patients with hematological malignancies.

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Favorable outcome of chronic disseminated candidiasis in four pediatric patients with hematological malignancies.

Med Mycol. 2012 Apr;50(3):315-9

Authors: Donker AE, Mavinkurve-Groothuis AM, van Die LE, Verweij PE, Hoogerbrugge PM, Warris A

Abstract
Four children were diagnosed with chronic disseminated candidiasis (CDC) during treatment for hematological malignancies. All presented with persistent fever, not responsive to broad-spectrum antibiotics, abdominal distension and hepatosplenomegaly. Two children needed artificial ventilation because of respiratory insufficiency. The time between onset of neutropenic fever and diagnosis of CDC ranged from 20-49 days. Ultrasound and computed tomography failed to demonstrate CDC during the neutropenic phase. All children needed a liver or spleen biopsy to establish the diagnosis of CDC. Three of four patients continued chemotherapy during treatment for the fungal infection. All patients had a favorable outcome, both in terms of the invasive Candida infections, as well as their underlying malignancies.

PMID: 22103343 [PubMed - indexed for MEDLINE]