Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.
J Nat Prod. 2015 Aug 18;
Authors: Rees KA, Bermudez C, Edwards DJ, Elliott AG, Ripen JE, Seta C, Huang JX, Cooper MA, Fraser JA, Yeo TC, Butler MS
In an ongoing program to identify new anti-infective leads, an extract derived from whole plant material of Desmodium congestum collected in the Sarawak rainforest was found to have anti-MRSA activity. Bioassay-guided isolation led to the isolation of two new prenylated chalcones, 5'-O-methyl-3-hydroxyflemingin A (1) and 5'-O-methylflemingin C (2), which were closely related to the flemingins previously isolated from various Flemingia species. Chalcones 1 and 2, which were determined to be 4:6 enantiomeric mixtures by chiral HPLC, exhibited moderate activity against a panel of Gram-positive bacteria and were also cytotoxic to the HEK293 human embryonic kidney cell line.
PMID: 26284978 [PubMed - as supplied by publisher]