Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.

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Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.

J Nat Prod. 2015 Aug 18;

Authors: Rees KA, Bermudez C, Edwards DJ, Elliott AG, Ripen JE, Seta C, Huang JX, Cooper MA, Fraser JA, Yeo TC, Butler MS

Abstract
In an ongoing program to identify new anti-infective leads, an extract derived from whole plant material of Desmodium congestum collected in the Sarawak rainforest was found to have anti-MRSA activity. Bioassay-guided isolation led to the isolation of two new prenylated chalcones, 5'-O-methyl-3-hydroxyflemingin A (1) and 5'-O-methylflemingin C (2), which were closely related to the flemingins previously isolated from various Flemingia species. Chalcones 1 and 2, which were determined to be 4:6 enantiomeric mixtures by chiral HPLC, exhibited moderate activity against a panel of Gram-positive bacteria and were also cytotoxic to the HEK293 human embryonic kidney cell line.

PMID: 26284978 [PubMed - as supplied by publisher]