Fluconazole Prophylaxis Against Invasive Candidiasis in Very Low and Extremely Low Birth Weight Preterm Neonates: A Systematic Review and Meta-Analysis.

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Fluconazole Prophylaxis Against Invasive Candidiasis in Very Low and Extremely Low Birth Weight Preterm Neonates: A Systematic Review and Meta-Analysis.

Clin Exp Pediatr. 2020 May 14;:

Authors: Robati Anaraki M, Nouri-Vaskeh M, Abdoli Oskoei S

Abstract
Evidence shows fluconazole prophylaxis is an effective treatment against invasive fungal infections in preterm neonates but efficient schedules of fluconazole prophylaxis on colonization and mortality of invasive candidiasis (IC) is unknown. The aim of this systematic review and meta-analysis was to assess the efficiency of different schedules of prophylactic fluconazole on fungal colonization, IC infection, and mortality of IC in very low birth weight (VLBW) end extremely low birth weight (ELBW) infants in neonatal intensive care units (NICUs). This is a meta-analysis study with search at PubMed, Scopus, Embase and Cochrane databases. The keywords were "candida", "invasive candidiasis", "IC", "fluconazole prophylaxis", "preterm infants", "very low birth weight infants", "VLBW", "extremely low birth weight", and "ELBW". Mortality is decreased significantly in meta-analysis of studies in different regimen of fluconazole prophylaxis. Also this meta-analysis indicated to significant decrease in incidence of IC-associated mortality in ELBW infants in same schedules of prophylaxis with fluconazole. The following studies should be designed to explore the effectiveness of other different schedules of prophylaxis with fluconazole on IC, fungal colonization and mortality.

PMID: 32683818 [PubMed - as supplied by publisher]