Ertapenem

Subcutaneously administered antibiotics.

Med Mal Infect. 2019 Jul 09;:

Authors: Colin E, Baldolli A, Verdon R, Saint-Lorant G

Abstract
The subcutaneous route is a widely used route of administration in routine clinical practice, particularly in elderly patients, when the intravenous route cannot be used. This review of the literature highlights the lack of randomized studies and the lack of pharmacokinetic data on the use of this route of administration. Three antibiotics administered subcutaneously can be used for severe infections, with acceptable pharmacokinetic and pharmacodynamic data, when the intravenous administration is not possible: ceftriaxone, ertapenem, and teicoplanin.

PMID: 31300245 [PubMed - as supplied by publisher]

Pseudoaneurysm formation after Pasteurella multocida lower extremity vascular bypass graft infection.

J Vasc Surg Cases Innov Tech. 2019 Sep;5(3):232-234

Authors: Ferrari-Light D, Zimmermann E, Sundaram V, Lee AM

Abstract
Prosthetic vascular bypass graft infection is a rare complication requiring prompt identification and isolation of the organism. A 66-year-old woman developed left lower extremity pain and a pulsatile pseudoaneurysm 7 months after left common femoral to peroneal artery bypass with prosthetic polytetrafluoroethylene graft, requiring re-exploration and a jump graft. Pasteurella multocida was isolated from blood and tissue culture specimens, and the patient admitted to a new kitten that frequently bit her lower extremities. Treatment included intravenous administration of ertapenem for 6 weeks followed by lifelong oral antibiotic suppression, which may offer the best chance for limb salvage when total graft explantation would result in amputation.

PMID: 31297473 [PubMed]