Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates.

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Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates.

Antimicrob Agents Chemother. 2013 Oct 14;

Authors: Castanheira M, Woosley LN, Messer SA, Diekema DJ, Jones RN, Pfaller MA

Abstract
Among 119 echinocandin non-wildtype (WT) Candida glabrata from two global surveys, mutations in fks hotspots (HS) were detected in 28 strains (7 countries; 8 USA states): 24 (85.7%) were non-WT for micafungin, 22 (78.6%) for anidulafungin, and 25 (89.3%) for caspofungin. Most common FKS substitutions among non-WT strains were at positions F659 (n=7) and S663 (n=7). Three isolates displaying WT MIC results had substitutions of F625Y, L630I, and D632Y or non-HS mutations. Mutations that have been reported to decrease the echinocandin binding to the1,3 β-D-glucan synthase were categorized as resistant by applying the new CLSI breakpoint criteria for all three echinocandins.

PMID: 24126582 [PubMed - as supplied by publisher]