Fungal cell membrane - promising drug target for antifungal therapy.
J Appl Microbiol. 2016 Sep 26;
Authors: Sant DG, Tupe SG, Ramana CV, Deshpande MV
Increase in invasive fungal infections over past few years especially in immunocompromised patients prompted the search for new antifungal agents with improved efficacy. Current antifungal armory includes very few effective drugs like Amphotericin B, new generation azoles including voriconazole and posaconazole, echinocandins like caspofungin, micafungin, to name a few. Azole class of antifungals which target fungal cell membrane are first choice of treatment for many years because of their effectiveness. As fungal cell membrane is predominantly made up of sterols, glycerophospholipids and sphingolipids, the role of lipids in pathogenesis and target identification for improved therapeutics were largely pursued by researchers during last few years. Present review focuses on cell membrane as antifungal target with emphasis on membrane biogenesis, structure and function of cell membrane, cell membrane inhibitors, screening assays, recent advances and future prospects. This article is protected by copyright. All rights reserved.
PMID: 27667746 [PubMed - as supplied by publisher]