Galactomannan antigenemia as a biomarker for therapeutic response of invasive aspergillosis: implications for clinical trial design and patient care.
Expert Rev Mol Diagn. 2018 Jun 13;:
Authors: McCarthy MW, Walsh TJ
INTRODUCTION: Clinical trials for invasive pulmonary aspergillosis, a potentially lethal mold infection, are complex investigations that require protracted time and extensive resources, delaying the development of new antifungal agents for this important disease. Areas Covered: In this paper, the authors examine a novel approach to study invasive pulmonary aspergillosis in humans, with a focus on the potentials and pitfalls of surrogate endpoints such as galactomannan antigenemia to evaluate therapeutic response to novel compounds. Expert Commentary: The authors believe the use of serum galactomannan as a primary endpoint in clinical trials may allow for development studies that could be accomplished with fewer resources. It is widely appreciated that serum galactomannan values strongly correlate with outcome of invasive aspergillosis in patients with hematologic cancer and may be applicable to other at-risk patient populations.
PMID: 29897826 [PubMed - as supplied by publisher]