Genetic context of <em>optrA</em> and <em>poxtA</em> in florfenicol-resistant enterococci isolated from flowing surface water in Switzerland

Antimicrob Agents Chemother. 2021 Jul 12:AAC0108321. doi: 10.1128/AAC.01083-21. Online ahead of print.

ABSTRACT

Linezolid is an important last-resort antibiotic for the treatment of multi-drug resistant enterococci. The aim of this study was to further characterize the genetic context of optrA and poxtA in ten florfenicol-resistant enterococci isolated from flowing surface water. In most genomes, optrA and poxtA were embedded in transposition units integrated into plasmids or into the chromosomal radC. For the first time a chromosomally integrated optrA in an Enterococcus raffinosus isolate is described.

PMID:34252296 | DOI:10.1128/AAC.01083-21