Global Trends in the Distribution of Candida Species Causing Candidemia.
Clin Microbiol Infect. 2014 Feb 10;
Authors: Guinea J
Only 5 species account for 92% of cases of candidemia (Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei); however their distribution varies in population-based studies conducted in different geographic areas. C. albicans is the most frequent species, but considerable differences are found between the number of cases caused by C. glabrata and the number caused by C. parapsilosis. Studies from Northern Europe and the USA reported a high number of cases caused by C. glabrata, whereas studies from Spain and Brazil demonstrated a lower number of cases caused by C. glabrata and a higher number of cases attributed to C. parapsilosis. Although C. albicans remains the most common species worldwide, its frequency is decreasing. In the case of C. glabrata and C. krusei, frequency is stable, although that of C. parapsilosis and C. tropicalis is increasing. The kind of patient and the antifungal agents received also have a considerable influence on the distribution and frequency of Candida spp., regardless of the geographic area. C. albicans is more frequent in patients aged up to 18 years. Interestingly, the frequency of C. parapsilosis decreases with age, whereas C. glabrata is more common in the elderly. Finally, the presence of horizontal transmission of Candida spp. isolates (reported mainly in patients from the adult medical and post-surgical ICU, patients from oncology-hematology units, and neonates) can affect species distribution. This article is protected by copyright. All rights reserved.
PMID: 24506442 [PubMed - as supplied by publisher]