Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study.

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Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study.

Int J Pharm Pract. 2019 May 06;:

Authors: Letswee G, Kamau H, Gaida R, Truter I

Abstract
OBJECTIVES: Identify the incidence of haematological adverse effects associated with linezolid.
METHODS: Medical records of 27 hospitalised patients in South Africa with drug-resistant tuberculosis (DR-TB) and prescribed linezolid therapy were retrospectively reviewed.
KEY FINDINGS: Approximately a quarter (n = 7) of patients experienced haematological adverse effects. These included anaemia (14.8%; n = 4), low haemoglobin (7.4%; n = 2) and macrocytosis (3.7%; n = 1). All patients who exhibited haematological adverse effects were living with HIV.
CONCLUSION: The haematological effects of linezolid manifested in patients who were suffering from co-morbid HIV. Haematological monitoring should be done monthly in order to detect adverse effects timeously and intervene as appropriate.

PMID: 31058394 [PubMed - as supplied by publisher]