In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules.

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In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules.

Drug Discov Today. 2014 Nov;19(11):1721-30

Authors: Wong SS, Samaranayake LP, Seneviratne CJ

Abstract
Candida infections have created a great burden on the public healthcare sector. The situation is worsened by recent epidemiological changes. Furthermore, the current arsenal of antifungal agents is limited and associated with undesirable drawbacks. Therefore, new antifungal agents that surpass the existing ones are urgently needed. High-throughput screening of small molecule libraries enables rapid hit identification and, possibly, increases hit rate. Moreover, the identified hits could be associated with unrecognized or multiple drug targets, which would provide novel insights into the biological processes of the pathogen. Hence, it is proposed that high-throughput screening of small molecules is particularly important in the pursuit of the ideal antifungal agents for Candida infections.

PMID: 24952336 [PubMed - indexed for MEDLINE]