In search of novel protein drug targets for treatment of Enterococcus faecalis infections.

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In search of novel protein drug targets for treatment of Enterococcus faecalis infections.

Chem Biol Drug Des. 2019 Jul 01;:

Authors: Singh H, Das S, Yadav J, Srivastava VK, Jyoti A, Kaushik S

Abstract
Enterococcus faecalis (Ef) is one of the major pathogen involved in hospital-acquired infections. It can cause nosocomial bacteremia, surgical wound infection and urinary tract infection. It is important to mention here that Ef is developing resistance against many commonly occurring antibiotics. The occurrence of multi-drug resistance (MDR) and extensive-drug resistance (XDR) is now posing a major challenge to the medical community. In this regard to combat the infections caused by Ef, we have to look for an alternative. Rational structure-based drug design exploits the three-dimensional structure of the target protein, which can be unravelled by various techniques like x-ray crystallography or Nuclear Magnetic Resonance (NMR) Spectroscopy. In this review, we have discussed the complete picture of Ef infections, the possible treatment available at present and the alternative treatment options to be explored. This study will help in better understanding of novel biological targets against Ef and the compounds, which are likely to bind with these targets. Using this detailed structural information, a rational structure-based drug design is achievable and the tight inhibitors against Ef can be prepared. This article is protected by copyright. All rights reserved.

PMID: 31260188 [PubMed - as supplied by publisher]