In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species.

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In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species.

Antimicrob Agents Chemother. 2015 Jun 22;

Authors: Skóra M, Bulanda M, Jagielski T

Abstract
The in vitro activities of eleven antifungal drugs against 68 Scopulariopsis and Microascus strains were investigated. Amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole, and ciclopirox showed either no or only poor antifungal effect. The best activity exhibited terbinafine and caspofungin. The MIC/MEC ranges were 0.0313->16 μg/ml and 0.125-16 μg/ml, MIC/MEC modes 1 μg/ml, MIC50/MEC50 1 μg/ml, and MIC90/MEC90 4 μg/ml and 16 μg/ml, respectively.

PMID: 26100698 [PubMed - as supplied by publisher]