In Vitro Activity of Eight Antifungal Drugs Against a Global Collection of Genotyped Isolates of Exserohilum.

In Vitro Activity of Eight Antifungal Drugs Against a Global Collection of Genotyped Isolates of Exserohilum.

Antimicrob Agents Chemother. 2015 Aug 3;

Authors: Chowdhary A, Hagen F, Curfs-Breuker I, Madrid H, de Hoog GS, Meis JF

Abstract
In vitro susceptibilities of 24 worldwide Exserohilum isolates belonging to 10 species from human and environmental sources were determined for eight antifungal drugs. Strains were characterized by ITS sequencing and Amplified Fragment Length Polymorphism fingerprinting. Posaconazole had the lowest geometric mean MIC (0.16 μg/ml) followed by micafungin (0.21 μg/ml), amphotericin B (0.24 μg/ml), itraconazole (0.33 μg/ml), voriconazole (0.8 μg/ml), caspofungin (1.05 μg/ml), isavuconazole (1.38 μg/ml) and fluconazole (15.6 μg/ml).

PMID: 26239995 [PubMed - as supplied by publisher]