In Vitro Interactions of Antifungal agents and Tacrolimus against Aspergillus Biofilms.

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In Vitro Interactions of Antifungal agents and Tacrolimus against Aspergillus Biofilms.

Antimicrob Agents Chemother. 2015 Aug 24;

Authors: Gao L, Sun Y

Abstract
Aspergillus biofilms were prepared from Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus, respectively, via a 96-well plate-based method and the combined antifungal activity of tacrolimus with azoles or amphotericin B against Aspergillus biofilms was investigated via broth microdilution checkerboard technique system. Our results suggest that combinations of tacrolimus with voriconazole or amphotericin B have synergistic inhibitory activity against Aspergillus biofilms. However, combinations of tacrolimus with itraconazole or posaconazole exhibit no synergistic or antagonistic effects.

PMID: 26303797 [PubMed - as supplied by publisher]