In vivo efficacy of ellagic acid against Candida albicans in a Drosophila melanogaster infection model.

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In vivo efficacy of ellagic acid against Candida albicans in a Drosophila melanogaster infection model.

Antimicrob Agents Chemother. 2018 Sep 24;:

Authors: Sampaio ADG, Gontijo AVL, Araujo HM, Koga-Ito CY

Abstract
The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans was inoculated in Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of Drosophila melanogaster from fungal infection was observed at non-toxic concentrations. This study showed that EA is promising for the treatment of candidiasis.

PMID: 30249692 [PubMed - as supplied by publisher]