In vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.

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In vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.

Antimicrob Agents Chemother. 2019 Apr 29;:

Authors: Lepak AJ, Zhao M, Marchillo K, VanHecker J, Andes DR

Abstract
Omadacycline is a novel aminomethylcycline antibiotic with potent activity against Staphylococcus aureus, including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in the neutropenic murine thigh model. The median 24h AUC/MIC associated with net stasis and 1-log kill was 21.9 and 57.7, respectively.

PMID: 31036691 [PubMed - as supplied by publisher]