Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin.

Related Articles

Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin.

Chem Commun (Camb). 2017 May 08;:

Authors: Chang J, Coffman L, Kim SJ

Abstract
The mode of action for desleucyl-oritavancin was investigated by adding an antibiotic to Staphylococcus aureus during its growth in a defined medium containing l,d-[1-(15)N]Ala and l-[1-(13)C]Lys, or d-[1-(15)N]Ala. (13)C{(15)N} and (15)N{(13)C} rotational-echo double resonance NMR determined that desleucyl-oritavancin inhibited the incorporation of d-[1-(15)N]Ala into wall teichoic acid.

PMID: 28480909 [PubMed - as supplied by publisher]