Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens.

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Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens.

Antimicrob Agents Chemother. 2014 Feb 24;

Authors: Seyedmousavi S, Brüggemann RJ, Melchers WJ, Verweij PE, Mouton JW

Abstract
Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole exposure (AUC0-24, area under the plasma concentration-time curve) in ELF was 20- to 31% of that in plasma for total drug after the third dose, and the relationship between plasma and ELF exposure was linear (r(2)=0.97, P=0.016).

PMID: 24566183 [PubMed - as supplied by publisher]