Linezolid-induced serotonin syndrome

Ind Psychiatry J. 2020 Jul-Dec;29(2):345-348. doi: 10.4103/ipj.ipj_37_19. Epub 2021 Mar 15.


Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid, when used alone. In this report, we present the case of a 70-year-old female who developed features of SS while being treated with linezolid 600 mg twice daily for pneumonia. The SS in her case was managed with stoppage of linezolid, administration of cyproheptadine, and supportive measures.

PMID:34158725 | PMC:PMC8188929 | DOI:10.4103/ipj.ipj_37_19