Macrocarpal-like compounds from Eugenia umbelliflora fruits and their antibacterial activity.
J Agric Food Chem. 2015 Aug 26;
Authors: Faqueti LG, Farias IV, Sabedot EC, Delle Monache F, San Feliciano A, Schuquel IT, Cechinel-Filho V, Bella Cruz A, Meyre-Silva C
The genus Eugenia are used as feed. One of its species is Eugenia umbelliflora, which is used for its fruits. The aim of the study was to isolate the constituents of the CH2Cl2 fraction obtained from Eugenia umbelliflora O. Berg (Myrtaceae), and also to evaluate its antimicrobial properties. Two novel meroterpenoids, eugenial C (3) and eugenial D (4), were isolated from the unripe fruits of Eugenia umbelliflora, and their structures established mainly by extensive NMR spectroscopy. In previous studies, the CH2Cl2 extract showed significant antibacterial activity, this activity can be attributed to meroterpenoids isolated in this study. The compounds eugenial C and D exhibited potent activity against B. subtilis and S. aureus and different strains of MRSA, and similar activity to the antibiotics used in antimicrobial therapies. The results demonstrate the antimicrobial potential of compounds eugenial C and D isolated from the unripe fruits of Eugenia umbelliflora, these compounds showed equivalent activity to antibiotics commonly used in anti-infection therapy.
PMID: 26308768 [PubMed - as supplied by publisher]