Pediatric Infectious Disease Journal:
POST ACCEPTANCE, 24 August 2012
Brief reports: PDF Only
Maternal Antibiotic Exposure and Risk of Antibiotic Resistance in Neonatal Early-Onset Sepsis: A Case-Cohort Study
Wright, Alissa Jade MD; Unger, Sharon MD; Coleman, Brenda L. PhD; Lam, Po-Po MSc; McGeer, Allison J. MSc, MD
In a case-cohort study of early-onset sepsis, antibiotic resistance was more likely for infections in neonates born to mothers given antibiotics during pregnancy (OR 4.6, 95% CI 1.1-19, P=.05). Risk of resistance increased with duration of antibiotics and number of antibiotic courses during pregnancy. Preterm birth and hospitalization during pregnancy were also associated with resistance. These risk factors should be considered when selecting empiric antibiotics for therapy of early-onset sepsis in infants.
(C) 2012 Lippincott Williams & Wilkins, Inc.