Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria.
Angew Chem Int Ed Engl. 2019 Oct 31;:
Authors: Chen H, Li S, Wu M, Kenry K, Huang Z, Lee CS, Liu B
Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to provide superefficient 1O2 generation specifically on bacteria membrane. TBD-anchor possesses energy donor and acceptor subunits to modulate the bandgap of the PS, and cationic groups were introduced to target bacterial membrane through electrostatic and hydrophobic interactions. TBD-anchor showed superefficient antibacterial performance towards both Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus). Over 99.8% killing efficiency was obtained for Methicillin-Resistant Staphylococcus aureus (MRSA) when they were exposed to 0.8 μM of TBD-anchor at a low white light dose (25 mW/cm2) for 10 minutes. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria.
PMID: 31670869 [PubMed - as supplied by publisher]