Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.

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Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.

Emerg Microbes Infect. 2020 Jun 23;:1-32

Authors: Swain SS, Sharma D, Hussain T, Pati S

Abstract
Nowadays, drug-resistant tuberculosis (DR-TB) and co-infected tuberculosis (CI-TB) strains are the leading cause for the enhancement of long-mortality and unpredicted mortality rates from this ghoulish acid fast-bacterium infection, globally. Unfortunately, the lack/ample lethargic towards the development of compelling anti-regimens with a large scale prevalence rate is a great challenge towards control of the pandemic situation. Indeed, the recent improvement in genomic studies for early diagnosis and understanding the mechanisms of drug resistance, as well as the identification of newer drug targets is quite remarkable and promising. Mainly, identification of such genetic factors, chromosomal mutations and associated pathways gives a new ray in current anti-TB drug discovery. This focused review provides molecular insights regarding update drug resistance mechanisms with encoded bacilli genetic factors as a novel target and potential source of development with screened-out newer anti-TB agents towards control of MDR-TB soon.

PMID: 32573374 [PubMed - as supplied by publisher]