Multi-mechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection

Antimicrob Agents Chemother. 2021 Apr 26:AAC.01832-20. doi: 10.1128/AAC.01832-20. Online ahead of print.

ABSTRACT

In a rabbit model of methicillin-resistant S. aureus prosthetic joint infection, prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reductions in joint swelling, erythema, intra-articular pus, and bacterial burden in synovial tissues and biofilm-associated prosthetic implants when compared with isotype-matched control IgG. Targeting specific staphylococcal virulence factors could thus have potential clinical utility for prevention of prosthetic joint infection.

PMID:33903108 | DOI:10.1128/AAC.01832-20