New library of pyrazole-imidazo[1,2-α]pyridine molecular conjugates: Synthesis, antibacterial activity and molecular docking studies.

New library of pyrazole-imidazo[1,2-α]pyridine molecular conjugates: Synthesis, antibacterial activity and molecular docking studies.

Chem Biol Drug Des. 2019 Oct 03;:

Authors: Ebenezer O, Awolade P, Koorbanally N, Singh P

Abstract
A library of novel pyrazole-imidazo[1,2-α]pyridine scaffolds was designed and synthesized through a one-potthree-component tandem reaction. The structures of synthesized conjugates were confirmed by spectroscopic techniques (NMR, IR and HRMS). In vitro antibacterial evaluation of the twelve synthesized molecules (7a, 8a-k) against Methicillin-resistant Staphylococcus aureus and normal strains of E.coli, S.Typhimurium, K.pneumonia, P.aeruginosa established 8b, 8d, 8e, 8h and 8i as potent antibacterial agents with superior minimum bactericidal concentration (MBC), compared to standard drug Ciprofloxacin. Molecular docking studies of all active compounds into the binding site of glucosamine-6-phosphate synthase were further performed in order to have a comprehensive understanding into putative binding modes within the active sites of the receptor.

PMID: 31580533 [PubMed - as supplied by publisher]