Oritavancin in vitro activity against contemporary Staphylococcus aureus isolates responsible for invasive community- and healthcare-associated infections among patients in the United States (2013-2014).

Oritavancin in vitro activity against contemporary Staphylococcus aureus isolates responsible for invasive community- and healthcare-associated infections among patients in the United States (2013-2014).

Diagn Microbiol Infect Dis. 2016 Jul 27;

Authors: Duncan LR, Sader HS, Flamm RK, Jones RN, Mendes RE

Abstract
Oritavancin has been approved in the United States and European Union for the treatment of acute bacterial skin and skin structure infections caused by several Gram-positive pathogens including Staphylococcus aureus. In this study, the in vitro activity of oritavancin and comparator agents was assessed against 1008 isolates of contemporary invasive community- or healthcare-associated S. aureus (790 and 218 isolates, respectively). All sampled contemporary (2013-2014) S. aureus isolates were susceptible at ≤0.12μg/mL to oritavancin (MIC50/90 values, 0.03/0.06μg/mL), regardless of origin or susceptibility phenotype.

PMID: 27543378 [PubMed - as supplied by publisher]