Oritavancin Pharmacokinetics and Bone Penetration in Rabbits.

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Oritavancin Pharmacokinetics and Bone Penetration in Rabbits.

Antimicrob Agents Chemother. 2015 Aug 3;

Authors: Lehoux D, Ostiguy V, Cadieux C, Malouin M, Belanger O, Rafai Far A, Parr TR

Abstract
Oritavancin pharmacokinetics and bone concentrations were investigated after a single intravenous dose was administered to rabbits. The pharmacokinetic profile of oritavancin in rabbits showed that it is rapidly distributed to bone tissues, with concentrations remaining stable for up to 168 h, the last measured time point. Based on these findings, further evaluation of oritavancin in the treatment of infections found in bone tissues is warranted.

PMID: 26239977 [PubMed - as supplied by publisher]