Currently browsing

Page 1300

Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron, Rochester, Minnesota 2014.

Related Articles

Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron, Rochester, Minnesota 2014.

Antimicrob Agents Chemother. 2015 May 4;

Authors: Sadarangani SP, Cunningham SA, Jeraldo PR, Wilson JW, Khare R, Patel R

Abstract
Emerging antimicrobial resistance in members of the Bacteroides fragilis group is a concern in clinical medicine. Although both metronidazole and carbapenem resistance have been reported in B. thetaiotaomicron, a member of the B. fragilis group, they have not, to the best of our knowledge, been reported together in the same B. thetaiotaomicron isolate. Herein we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistant B. thetaiotaomicron from a patient with post-operative intra-abdominal abscess and empyema. Whole genome sequencing demonstrated the presence of nimD with at least a portion of IS1169 upstream, a second putative nim gene, two β-lactamase genes, one of which has not been previously reported, two tetX genes, tetQ, ermF, two cat genes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance in B. thetaiotaomicron and the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.

PMID: 25941219 [PubMed – as supplied by publisher]

[Skin symptoms associated with human immunodeficiency virus infection].

Related Articles

[Skin symptoms associated with human immunodeficiency virus infection].

Orv Hetil. 2015 Jan 4;156(1):10-8

Authors: Tamási B, Marschalkó M, Kárpáti S

Abstract
The recently observed accelerated increase of human immunodeficiency virus infection in Hungary poses a major public concern for the healthcare system. Given the effective only but not the curative therapy, prevention should be emphasized. Current statistics estimate that about 50% of the infected persons are not aware of their human immunodeficiency virus-positivity. Thus, early diagnosis of the infection by serological screening and timely recognition of the disease-associated symptoms are crucial. The authors’ intention is to facilitate early infection detection with this review on human immunodeficiency virus-associated skin symptoms, and highlight the significance of human immunodeficiency virus care in the everyday medical practice.

PMID: 25544049 [PubMed – indexed for MEDLINE]

Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.

Related Articles

Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.

Immunity. 2015 Feb 17;42(2):356-66

Authors: Kashem SW, Igyártó BZ, Gerami-Nejad M, Kumamoto Y, Mohammed J, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, Iwasaki A, Brown GD, Kaplan DH

Abstract
Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells. Filamentous forms induced Th1 without Th17 cell responses due to the absence of Dectin-1 ligation. Notably, Th17 cell responses provided protection against cutaneous infection while Th1 cell responses provided protection against systemic infection. Thus, C. albicans morphology drives distinct T helper cell responses that provide tissue-specific protection. These findings provide insight into compartmentalization of Th cell responses and C. albicans pathogenesis and have critical implications for vaccine strategies.

PMID: 25680275 [PubMed – indexed for MEDLINE]

How to treat fungal infections in ICU patients.

Related Articles
How to treat fungal infections in ICU patients.
BMC Infect Dis. 2015 May 2;15(1):205
Authors: Matthaiou DK, Christodoulopoulou T, Dimopoulos G
Abstract
Fungal infections represent a …