Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron, Rochester, Minnesota 2014.
Antimicrob Agents Chemother. 2015 May 4;
Authors: Sadarangani SP, Cunningham SA, Jeraldo PR, Wilson JW, Khare R, Patel R
Emerging antimicrobial resistance in members of the Bacteroides fragilis group is a concern in clinical medicine. Although both metronidazole and carbapenem resistance have been reported in B. thetaiotaomicron, a member of the B. fragilis group, they have not, to the best of our knowledge, been reported together in the same B. thetaiotaomicron isolate. Herein we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistant B. thetaiotaomicron from a patient with post-operative intra-abdominal abscess and empyema. Whole genome sequencing demonstrated the presence of nimD with at least a portion of IS1169 upstream, a second putative nim gene, two β-lactamase genes, one of which has not been previously reported, two tetX genes, tetQ, ermF, two cat genes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance in B. thetaiotaomicron and the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.
PMID: 25941219 [PubMed – as supplied by publisher]