Pharmacokinetics of Caspofungin in Critically Ill Patients on Continuous Renal Replacement Therapy.
Antimicrob Agents Chemother. 2013 Jun 3;
Authors: Weiler S, Seger C, Pfisterer H, Stienecke E, Stippler F, Welte R, Joannidis M, Griesmacher A, Bellmann R
Caspofungin pharmacokinetics was assessed in 27 critically ill patients, 7 on continuous veno-venous hemofiltration (CVVH), 8 on continuous veno-venous hemodialysis (CVVHD) and 13 patients not requiring continuous renal replacement therapy (CRRT). Caspofungin exposure during CRRT was very similar to that of the control group and comparable with that in healthy volunteers. Caspofungin clearance by CRRT was very low. Therefore, standard dosage of caspofungin is probably adequate for critically ill patients undergoing CVVH or CVVHD.
PMID: 23733471 [PubMed - as supplied by publisher]