Pharmacokinetics of caspofungin increased dosage in a patient on rifampin-containing anti-tubercular treatment.
Scand J Infect Dis. 2013 Jun 24;
Authors: Calcagno A, Baietto L, Pagani N, Bertucci R, Rostagno R, D'Avolio A, Di Perri G, De Rosa FG
We describe a patient treated with caspofungin and rifampin; after increasing the dosage of the former (70 mg/day) we observed an unexpectedly lower plasma exposure (AUC0-24 79.5 μg/ml*h vs. 108.8 μg/ml*h). Although rifampin-mediated complete enzyme induction may take longer than 2 weeks, the clinical advantage of an increased caspofungin dose deserves clinical investigation.
PMID: 23796067 [PubMed - as supplied by publisher]