Plasma and Cerebrospinal Fluid Therapeutic Drug Monitoring of Ceftolozane and Tazobactam During Treatment of Multidrug-Resistant Pseudomonas aeruginosa Meningitis

Open Forum Infect Dis. 2020 Nov 12;7(12):ofaa549. doi: 10.1093/ofid/ofaa549. eCollection 2020 Dec.


We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and cerebral spinal fluid. The data suggest that ceftolozane-tazobactam may be an option for select central nervous system infections; however, treatment decisions should be interpreted on a case-by-case basis.

PMID:33409327 | PMC:PMC7751399 | DOI:10.1093/ofid/ofaa549