Posaconazole Induced Hypertension and Hypokalemia: In vivo 11β-hydroxysteroid dehydrogenase Inhibition.

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Posaconazole Induced Hypertension and Hypokalemia: In vivo 11β-hydroxysteroid dehydrogenase Inhibition.

Antimicrob Agents Chemother. 2017 May 22;:

Authors: Thompson GR, Chang D, Wittenberg RR, McHardy I, Semrad A

Abstract
We describe a case of apparent mineralocorticoid excess (AME) secondary to posaconazole and suggest the biochemical mechanism. Clinical and laboratory investigation confirmed 11β-hydroxysteroid dehydrogenase inhibition and withholding therapy led to a resolution of all clinical and laboratory abnormalities. A lower dose of posaconazole was later restarted and avoided recurrence of this syndrome. Additional studies are necessary to determine the frequency of posaconazole induced AME and whether other azole antifungals can be associated with this phenomenon.

PMID: 28533238 [PubMed - as supplied by publisher]