Posaconazole Plasma Concentrations on Day 3-5 Predict Steady State Levels.
Antimicrob Agents Chemother. 2016 Jun 20;
Authors: Prattes J, Duettmann W, Hoenigl M
Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady state PPCs (obtained between day 3-5) with those obtained during steady-state in 48 patients with underlying hematological malignancies receiving posaconazole oral solution prophylaxis. Pre-steady state PPCs correlated significantly with those obtained at steady-state (Spearman r=0.754, p<0.001). ROC curve analysis of pre-steady state PPCs revealed an AUC of 0.884 (95%CI 0.790-0.977) for predicting satisfactory PPCs at steady-state.
PMID: 27324763 [PubMed - as supplied by publisher]