Recent advances in indole dimers and hybrids with antibacterial activity against methicillin-resistant Staphylococcus aureus.

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Recent advances in indole dimers and hybrids with antibacterial activity against methicillin-resistant Staphylococcus aureus.

Arch Pharm (Weinheim). 2020 Sep 28;:e2000266

Authors: Meng T, Hou Y, Shang C, Zhang J, Zhang B

Abstract
Methicillin-resistant Staphylococcus aureus (MRSA), one of the major and most dangerous pathogens in humans, is a causative agent of severe pandemic of mainly skin and soft tissue and occasionally fatal infections. Therefore, it is imperative to develop potent and novel anti-MRSA agents. Indole derivatives could act against diverse enzymes and receptors in bacteria, occupying a salient place in the development of novel antibacterial agents. Dimerization and hybridization are common strategies to discover new drugs, and a number of indole dimers and hybrids possess potential antibacterial activity against a panel of clinically important pathogens including MRSA. Accordingly, indole dimers and hybrids are privileged scaffolds for the discovery of novel anti-MRSA agents. This review outlines the recent development of indole dimers and hybrids with a potential activity against MRSA, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective candidates.

PMID: 32986279 [PubMed - as supplied by publisher]