Recent Advances on Vaginal delivery for the Treatment of Vulvovaginal candidiasis.
Curr Mol Pharmacol. 2020 Jun 21;:
Authors: Kaur S, Kaur S
BACKGROUND: Vulvovaginal candidiasis (VVC) is a common vaginal infection caused by candida species, affecting 70% of the women. It may occur due to the imbalance in the vaginal micro-biodata, pregnancy, diabetes, use of antibiotics, frequent sexual activities or AIDS.
AIM: The main aim of this review is to provide overview about different vaginal delivery systems for the administration of antifungal agents like conventional, mucoadhesive and muco-penetrating delivery systems.
METHOD: The conventional delivery systems available are having limited efficacy due to the less residence time and adverse effects. In order to overcome these issues, delivery system with mucoadhesive and muco-penetrating properties is required. Mucoadhesive polymers are having excellent binding properties with mucin and thus increasing residence time. On the other hand, muco-penetrating polymers transport the antifungal agents across the mucus layer.
RESULTS: This review summarizes the pathophysiology of VVC along with novel delivery systems for the treatment of infection through mucoadhesive and muco-penetrating approaches. Surface modifications of nano/ microparticles with mucoadhesive or muco-penetrating particles may results delivery systems with improved therapeutic efficacy.
CONCLUSION: Based on the available data conventional and mucoadhesive drug delivery systems have some limitations, still requires improvement/ development for safe and effective delivery of antifungal agents.
PMID: 32564767 [PubMed - as supplied by publisher]