Recurrent fever of unknown fungal infection in a low-risk patient: A case report.

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Recurrent fever of unknown fungal infection in a low-risk patient: A case report.

Medicine (Baltimore). 2019 Aug;98(33):e16908

Authors: Guo TM, Ye Y, Huang LL, Cheng B

Abstract
RATIONALE: Fungal infectious disease does not usually occur in low-risk patients. Clinicians tend to ignore the role of fungi in the fevers of low-risk patients. If there is not timely control of fungal infections and associated fever, the disease will continue to worsen, resulting in physical dysfunction or death.
PATIENT CONCERNS: Recurrent fever continued for 1 month in a young adult.
DIAGNOSES AND INTERVENTIONS: Non-albicans Candida (NAC) species probably was the main pathogen in this case based on the resolution of fever after capsofungin administration.
OUTCOMES: The fever and the associated indicators, including white blood cell count, C-reaction protein, erythrocyte sedimentation rate, and BDG levels, showed improvement quickly. The patient left the hospital successfully after 18 days of caspofungin treatment. There was no recurrent fever at a follow-up of 1 year.
LESSONS: Clinicians should be aware that the incidence of fungal infection is increasing in low-risk patients. The BDG assay is still an effective tool used to diagnose invasive fungal diseases. Caspofungin is an effective drug for the treatment of some unknown fungal infections.

PMID: 31415438 [PubMed - in process]