Research progress of correlation between multidrug resistance and transporters and traditional Chinese medicine intervention

Zhongguo Zhong Yao Za Zhi. 2021 Jan;46(2):340-346. doi: 10.19540/j.cnki.cjcmm.20200602.201.


With the emergence of drug resistance in Western medicine, the repeated administration of clinical first-line drugs becomes more severe. There are many factors leading to multidrug resistance(MDR), so it is very difficult to solve the problem. Since traditional Chinese medicine(TCM) has been used in the field of MDR in recent years, the research on the transporter-associated drug resistance and intervention of TCM has gradually become a hot spot. Therefore, in order to further explore the relationships among drug resistance, transporters, and TCM intervention, we review the relevant research progress in recent years and comb the achievements and limitations of this research at present. In the end, we put forward the research direction of changing body's ADME through the host's transporters and gastrointestinal flora, which provides new ideas for future research.

PMID:33645120 | DOI:10.19540/j.cnki.cjcmm.20200602.201